To resolve the issue of Safari opening with antivirus spyware ads while playing Crossword Jam, follow these detailed steps:

1. Clear Safari Browsing Data:
- Open Safari.
- Click on “Safari” in the menu bar at the top.
- Select “Clear History…”.
- In the pop-up, choose “all history” from the dropdown menu.
- Click “Clear History” to confirm.

2. Block Pop-Ups:
- Go to “Safari” in the menu bar.
- Select “Preferences”.
- In the Preferences window, go to the “Websites” tab.
- Click on “Pop-up Windows” in the sidebar.
- Set the option to “Block and Notify” or “Block” for all websites.

3. Check for Malware:
- Download a reputable malware detection tool like Malwarebytes Anti-Malware for Mac here - [learn more].
- Install the software and run a comprehensive scan of your system.
- Follow the prompts to remove any detected malware or adware.

4. Reset Safari Settings:
- Open Safari and go back to “Preferences” from the menu.
- In the "General" tab, make sure that your default search engine is set to something you trust (like Google or Bing).
- Moreover, ensure that the homepage is also a known and trusted site.

5. Update Your MacOS and Safari:
- Go to the Apple menu and select “System Preferences”.
- Click on “Software Update” to check for updates.
- Install any available updates, as they may include security patches that can help prevent malicious ads.

6. Disable Unwanted Extensions:
- Open Safari and click on “Preferences”.
- Navigate to the “Extensions” tab.
- Review installed extensions and disable any that seem suspicious or are not needed.

7. Enable Warning for Dangerous Websites:
- In “Preferences” under the “Security” tab, enable “Warn when visiting a fraudulent website”.
- This setting can help protect you from malicious ads and the potential for spyware.

8. Restart Safari:
- After completing the above steps, close Safari completely and then reopen it to see if the problem persists.

By following these steps, you should be able to eliminate the ads that appear when playing Crossword Jam and enhance your browsing security. If the issue continues after completing these actions, consider reaching out to Apple Support for further assistance - learn more - learn more.